国家发育和功能人脑组织资源库（协和脑库）支持中国脑科学研究：
从2014年开始，协和脑库为国内25家研究单位的课题组提供了4000多例次人脑组织样
本，有力的支持了中国脑科学研究：包括医科院基础所、北京协和医院、实验动物所,北京医
院、湘雅医院、天坛医院、北京大学、清华大学、北京师范大学、复旦大学上海医学院、河北
医科大学、上海大瑞金医院、同济医学院等。合作单位利用我院人脑组织发表的论著：
1. Liu E, Zhou Q, Xie AJ, et al. Tau acetylates and stabilizes β-catenin thereby promoting cell survival. EMBO Rep. 2020;21(3):e48328. doi:10.15252/embr.201948328
2. Qin L, Xu Q, Li Z, Chen L, Li Y, Yang N, Liu Z, Guo J, Shen L, Allen EG, Chen C, Ma C, Wu H, Zhu X*, Jin P*, Tang B*. Ethnicity-specific and overlapping alterations of brain hydroxymethylome in Alzheimer’s disease. Human Molecular Genetics 29(1): 149–158, 2020. https://doi.org/10.1093/hmg/ddz273
3. Zheng J, Li HL, Tian N, et al. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission [published correction appears in Cell Stem Cell. 2020 Mar 5;26(3):462-466]. Cell Stem Cell. 2020;26(3):331-345.e6. doi:10.1016/j.stem.2019.12.015
4. Hu YB, Ren RJ, Zhang YF, Huang Y, Cui HL, Ma C, Qiu WY, Wang H, Cui PJ, Chen HZ, Wang G. Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology. Aging Cell e13001, 2019. https://doi.org/10.1111/acel.13001 PMID: 31287605
5. Zhang F, Wei J, Li X, Ma C, Gao Y. Early Candidate Urine Biomarkers for Detecting Alzheimer's Disease Before Amyloid-β Plaque Deposition in an APP (swe)/PSEN1dE9 Transgenic Mouse Model. J Alzheimers Dis. 2018;66(2):613-637. doi:10.3233/JAD-180412
6. Zhang L, Sun C, Jin Y, et al. Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2017;60(2):733-746. doi:10.3233/JAD-161254
7. Hu X, Hu ZL, Li Z, et al. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum. Front Neuroanat. 2017;11:45. Published 2017 Jun 7. doi:10.3389/fnana.2017.00045
8. Zhang C, Lu J, Liu B, Cui Q, Wang Y. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease. Aging (Albany NY). 2016;8(2):272-290. doi:10.18632/aging.100887
9. Griffith CM, Xie MX, Qiu WY, et al. Aberrant expression of the pore-forming KATP channel subunit Kir6.2 in hippocampal reactive astrocytes in the 3xTg-AD mouse model and human Alzheimer's disease. Neuroscience. 2016;336:81-101. doi:10.1016/j.neuroscience.2016.08.034
10. Zhang XM, Cai Y, Wang F, et al. Sp8 expression in putative neural progenitor cells in guinea pig and human cerebrum. Dev Neurobiol. 2016;76(9):939-955. doi:10.1002/dneu.22367
11. Zhu HX, Xue ZQ, Qiu WY, et al. Age-related intraneuronal accumulation of αII-spectrin breakdown product SBDP120 in the human cerebrum is enhanced in Alzheimer's disease. Exp Gerontol. 2015;69:43-52. doi:10.1016/j.exger.2015.06.003
12. Xue ZQ, He ZW, Yu JJ, et al. Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain. BMC Neurol. 2015;15:71. Published 2015 May 2. doi:10.1186/s12883-015-0327-z
协和脑库课题组（医科院基础所）发表研究成果（*通讯作者）
[科研论文]
1. Zhang W, Zhang Q, Yang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W*, Ma C*. (2020). Contribution of Alzheimer’s Disease Neuropathologic Change to the Cognitive Dysfunction in Human Brains with Lewy Body-Related Pathology. Neurobio Aging 91:56-65, 2020. https://doi.org/10.1016/j.neurobiolaging.2020.02.022
2. Wang X, Xia W, Li K, Zhang Y, Ge W*, Ma C*. Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse. J Neurol Sci 399:125-139, 2019.doi:10.1016/j.jns.2019.02.022
3. Xiong F, Ge W*, Ma C*. Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association15(3):429–440,2019. doi: 10.1016/j.jalz.2018.10.006.
4. Yang Q, Chen K, Zhang H, Zhang W, Gong C, Zhang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W*,Ma C*. Correlations between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease among Han Chinese. Neurosci Bull35(2):193-204, 2019 https://doi.org/10.1007/s12264-019-00343-2
5. Zhang Q, Zhang H, Liu F, Yang Q, Chen K, Liu P, Sun T, Ma C, Qiu W*, Qian X*. Comparison of Reference Genes for Transcriptional Studies in Postmortem Human Brain Tissues under Different Conditions. Neurosci Bull35(2):225-228, 2019. https://doi.org/10.1007/s12264-018-0309-4
6. Zhang H, Chen K, Wang N, Zhang D, Yang Q, Zhang Q, Liu P, Wang M, Gong C, Hong X, Qiu W, Qian X, Chen Y*, Ma C*. Analysis of Brain Donors' Demographic and Medical Characteristics to Facilitate the Construction of a Human Brain Bank in China. J Alzheimers Dis66:1245–1254, 2018. doi:10.3233/JAD-180779
7. Qiu W, Yang Q, Zhang W, Wang N, Zhang D, Huang Y, Ma C*. The Correlations Between Postmortem Brain Pathologies and Cognitive Dysfunction in Aging and Alzheimer’s Disease. Curr Alz Res15:1-12, 2018.doi:10.2174/1567205014666171106150915
8. Liu X, Guo Z, Liu W, Sun W*, Ma C*.Differential proteome analysis of hippocampus and temporal cortex using label-free based 2D-LC-MS/MS.J Proteomics165:26-34, 2017.doi:10.1016/j.jprot.2017.06.008
9. Qiu W, Guo X, Lin X, Yang Q, Zhang W, Zhang Y, Zuo L, Zhu Y, Li CR, Ma C*, Luo X*.Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease. Neurobio Aging 57:170-177, 2017.doi:10.1016/j.neurobiolaging.2017.05.020
10. Xu B, Xiong F, Tian R, Zhan S, Gao Y, Qiu W, Wang R, Ge W*, Ma C*. Temporal Lobe in Human Aging: a Quantitative Protein Profiling Study of Samples from Chinese Human Brain Bank. Exp Gerontol. 73:31-41, 2016.doi:10.1016/j.exger.2015.11.016
11. Xu B, Gao Y, Zhan S, Xiong F, Qiu W, Qian X, Wang T, Wang N, Zhang D, Yang Q, Wang R, Bao X, Dou W, Tian R, Meng S, Gai W, Huang Y, Yan X-X, Ge W*, Ma C*. Quantitative Protein Profiling of Hippocampus during Human Aging. Neurobio Aging 39:46-56, 2016.doi:10.1016/j.neurobiolaging.2015.11.029
12. 仇文颖，刘帆，杨倩，刘伟，王乃利，张迪，王涛，袁勃，马超*.人脑组织库样本100例质量及影响因素分析. 解剖学报 47(3):315-320, 2016.
[综述和论著]
13. Vornholt E, Luo D, Qiu W, McMichael GO, Liu Y, Gillespie N, Ma C*, Vladimirov VI*.Postmortem brain tissue as an underutilized resource to study the molecular pathology of neuropsychiatric disorders across different ethnic populations. Neurosci Biobehav Rev102:195-207, 2019.doi:10.1016/j.neubiorev.2019.04.015
14. Ma C*, Bao AM, Yan XX, Swaab DF. Progress in Human Brain Banking in China.Neurosci Bull.35(2):179-182, 2019.
15. Qiu W, Zhang H, Bao A, Zhu K, Huang Y, Yan X, Zhang J, Zhong C, Shen Y, Zhou J, Zheng X, Zhang L, Shu Y, Tang B, Zhang Z, Wang G, Zhou R, Sun B, Gong C, Duan S, Ma C*. Standardized Operational Protocol for Human Brain Banking in China.Neurosci Bull.35(2):270-276, 2019. doi:10.1007/s12264-018-0306-7
16. 仇文颖, 马超*, 包爱民 等. 中国人脑组织库标准化操作方案. 解剖学报48(3):282-289, 2017.
17. 仇文颖,马超*. 中国医学科学院北京协和医学院人脑组织库建设，基础医学与临床 “人脑组织库建设”专刊 34suppl: 71-75, 2014.
18. 刘帆，姜浩武，王乃利，张迪，王涛，袁勃，仇文颖，马超*. 中国医学科学院北京协和医学院人脑组织库脑组织质量检测与分析，基础医学与临床 “人脑组织库建设”专刊 34suppl: 87-95, 2014.
